ABSTRACT
OBJECTIVE: To assess the incidence of diagnosis of high-grade intraepithelial neoplasia or prostate intraepithelial neoplasia (PIN), and atypical small gland proliferation (ASAP) at a uropathology reference center. To assess the indexes and findings on repeat biopsies. MATERIALS AND METHODS: Diagnoses of PIN, ASAP or PIN + ASAP established between January 1, 2001 and December 31, 2003 were searched in our database. We studied repeat biopsies performed up to August 31, 2004. RESULTS: Of 1420 biopsies, ASAP was diagnosed in 26 (1.8 percent) patients, PIN in 142 (10 percent) and PIN + ASAP in 40 (2.8 percent). Repeat biopsies were performed in 98 patients, 16 (61.5 percent) with ASAP, 53 (37.3 percent) with PIN and 29 (72.5 percent) with PIN + ASAP. Carcinoma was diagnosed in 7 cases (43.8 percent) following a diagnosis of ASAP, 12 (41.4 percent) of PIN + ASAP and 7 (13.2 percent) of PIN. The mean interval between repeat biopsies was 299.6 days. There was no difference between groups where cancer was or was not diagnosed on repeat biopsy in relation to age and serum PSA levels. CONCLUSION: Despite explicit recommendations of repeat biopsy on pathology reports and the high incidence of adenocarcinoma on repeat biopsy, re-intervention rates following a diagnosis of PIN, ASAP, PIN + ASAP are low in our setting. The diagnosis that most frequently led to repeat biopsy was PIN + ASAP. Adenocarcinoma was most often diagnosed after the initial diagnosis of ASAP.
Subject(s)
Aged , Humans , Male , Middle Aged , Adenocarcinoma/diagnosis , Biopsy , Practice Patterns, Physicians'/statistics & numerical data , Prostatic Diseases/diagnosis , Prostatic Intraepithelial Neoplasia/diagnosis , Prostatic Neoplasms/diagnosis , Adenocarcinoma/epidemiology , Adenocarcinoma/pathology , Incidence , Precancerous Conditions , Prostatic Diseases/epidemiology , Prostatic Diseases/pathology , Prostatic Intraepithelial Neoplasia/epidemiology , Prostatic Intraepithelial Neoplasia/pathology , Prostatic Neoplasms/epidemiology , Prostatic Neoplasms/pathologyABSTRACT
Os autores apresentan o caso de uma mulher de 31 anos, internada com quadro de dor abdominal, febre, emagrecimento e hipertensäo arterial maligna. O exame ultra-sonográfico, realizado por ocasiäo da admissäo, mostrou a imagem sugestiva de nefropatia crônica. No 3§ dia de internaçäo, apresentou abdome agudo, sendo a paciente submetida a laparotomia exploradora, quando se evidenciou peritonite purulenta e segmento ileal com múltiplas perfuraçöes, que foi ressecado. O resultado do exame anatomopatológico do íleo ressecado revelou poliarterite nodosa. A paciente evoluiu com falência de multiplos órgäos e óbito. Comenta-se a dificuldade do diagnóstico e, com base em experiência de literatura, sugerem tratamento através de plasmaferese, tendo em vista que a terapêutica convencional com metilprednisolona e ciclosfosfamida mostrou-se, mais uma vez, insuficiente em casos graves